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Welcome to the PharmML website! PharmML stands for Pharmacometrics Markup Language - a new exchange format for encoding of models, associated tasks and their annotation as used in pharmacometrics. It is being developed by the DDMoRe consortium, an European Innovative Medicines Initiative (IMI) project

The lack of a common format which would allow for a smooth exchange of models between different software tools used in population pharmacokinetics/pharmacodynamics such as NONMEM, Monolix or BUGS has been a longstanding problem in the field. PharmML is being developed to become such standard.

The relationships of distributions  supported by ProbOnto 2.0 - Ontology and Knowledge Base of Probability Distributions - see project website probonto.org for more details. PharmML makes use of ProbOnto facilitating greatly the encoding of a large family of statistical models.



Recent Announcements

  • PharmML 0.9 is out! New in this version:Mixture models mixtures of distributionsmixtures of structural models (wsmm, bsmm)New DE notation - encodable are ODEs, DDEs & PDEs with boundary and initial conditionsAutocorrelation models ...
    Posted Jul 22, 2016, 5:54 AM by Maciek J Swat
  • ProbOnto 2.0 is out ...with new distributions (such as LogNormal7, parameterisation used in PopED, Trapezoidal1, HalfNormal2 and WienerDiffusionModel1)relationships (mostly re-parameterisations for LN7) and survival and hazard functions - see Exponential1 and Weibull1 for ...
    Posted Jul 20, 2016, 11:57 PM by Maciek J Swat
  • BMSS/SOT PharmML webinar - Friday, 22nd July Don’t miss the PharmML webinar (22 July 11:00 AM EDT / 4:00 PM CET) organised by Biological Modeling Specialty Section (BMSS) of the Society of Toxicology (SOT). PharmML ...
    Posted Jul 14, 2016, 3:08 AM by Maciek J Swat
  • ProbOnto paper accepted for publication! An application note on ProbOnto 1.0 has been accepted for publication in Bioinformatics!ProbOnto stands for 'Ontology and Knowledge Base of Probability Distributions' and has following features:Over 80 ...
    Posted Mar 24, 2016, 4:57 AM by Maciek J Swat
  • PharmML v0.8 New version of PharmML v0.8 is ready to download - with support for (optimal) trial design, Bayesian inference etc. It is a development version meaning no full spec is available ...
    Posted Jan 13, 2016, 9:13 AM by Maciek J Swat
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