'There is a certain obligation in science to be able to share our results in a way that are replicable with our colleagues'
 Richard McElreath, the author of Statistical Rethinking

Welcome to the PharmML website! PharmML stands for Pharmacometrics Markup Language - a new exchange format for encoding of models, associated tasks and their annotation as used in pharmacometrics. It is being developed by the DDMoRe consortium, an European Innovative Medicines Initiative (IMI) project

The lack of a common format which would allow for a smooth exchange of models between different software tools used in population pharmacokinetics/pharmacodynamics such as NONMEM, Monolix or BUGS has been a longstanding problem in the field. PharmML is being developed to become such standard.

The following figures visualises the development history of PharmML/SO and ProbOnto

Model Definition extensions in version 0.9 are indicated in the figure below

Recent Announcements

  • ProbOnto 2.5 release New in this release:- 44 additional uni- and multivariate distributions- Relationships/re-parameterisations, HFs and SFs- Model definitions added for the majority of distributions - Few bugs/typos fixed - see spec ...
    Posted Feb 9, 2017, 1:25 AM by Maciek J Swat
  • PharmML/SO talk at Combine 2016 PharmML & SO has been presented by Maciej J Swat at the COMBINE 2016 meeting in Newcastle upon Tyne (UK). Slides can be downloaded from DropBox: tinyurl.com/hl7atym
    Posted Sep 23, 2016, 1:48 AM by Maciek J Swat
  • PharmML 0.9 is out! New in this version:Mixture models mixtures of distributionsmixtures of structural models (wsmm, bsmm)New DE notation - encodable are ODEs, DDEs & PDEs with boundary and initial conditionsAutocorrelation models ...
    Posted Jul 22, 2016, 5:54 AM by Maciek J Swat
  • ProbOnto 2.0 is out ...with new distributions (such as LogNormal7, parameterisation used in PopED, Trapezoidal1, HalfNormal2 and WienerDiffusionModel1)relationships (mostly re-parameterisations for LN7) and survival and hazard functions - see Exponential1 and Weibull1 for ...
    Posted Jul 20, 2016, 11:57 PM by Maciek J Swat
  • BMSS/SOT PharmML webinar - Friday, 22nd July Don’t miss the PharmML webinar (22 July 11:00 AM EDT / 4:00 PM CET) organised by Biological Modeling Specialty Section (BMSS) of the Society of Toxicology (SOT). PharmML ...
    Posted Jul 14, 2016, 3:08 AM by Maciek J Swat
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