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'There is a certain obligation in science to be able to share our results in a way that are replicable with our colleagues'
 Richard McElreath, the author of Statistical Rethinking



Welcome to the PharmML website! PharmML stands for Pharmacometrics Markup Language - a new exchange format for encoding of models, associated tasks and their annotation as used in pharmacometrics. It has been developed by the DDMoRe consortium, an European Innovative Medicines Initiative (IMI) project

The lack of a common format which would allow for a smooth exchange of models between different software tools used in population pharmacokinetics/pharmacodynamics such as NONMEM, Monolix or BUGS has been a longstanding problem in the field. 

The following figures visualises the development history of PharmML/SO and ProbOnto


Model Definition extensions in version 0.9 are indicated in the figure below



Recent Announcements

  • Release of libsoc (0.6) with ability to reference PharmML files We are happy to announce that a new version of libsoc (0.6), the R package for reading and writing SO files, has been released to CRAN, provided by Rikard ...
    Posted Jan 13, 2018, 5:33 AM by Maciek J Swat
  • First release of pharmmlutils (pharmmltool) We are happy do announce the first release of pharmmlutils by Rikard Nordgren (Uppsala University), that currently contain pharmmltool. pharmmltool is a utility to validate PharmML 0.8.1 and ...
    Posted Aug 22, 2017, 7:02 AM by Maciek J Swat
  • ProbOnto 2.5 release New in this release:- 44 additional uni- and multivariate distributions- Relationships/re-parameterisations, HFs and SFs- Model definitions added for the majority of distributions - Few bugs/typos fixed - see spec ...
    Posted Feb 9, 2017, 1:25 AM by Maciek J Swat
  • PharmML/SO talk at Combine 2016 PharmML & SO has been presented by Maciej J Swat at the COMBINE 2016 meeting in Newcastle upon Tyne (UK). Slides can be downloaded from DropBox: tinyurl.com/hl7atym
    Posted Sep 23, 2016, 1:48 AM by Maciek J Swat
  • PharmML 0.9 is out! New in this version:Mixture models mixtures of distributionsmixtures of structural models (wsmm, bsmm)New DE notation - encodable are ODEs, DDEs & PDEs with boundary and initial conditionsAutocorrelation models ...
    Posted Jul 22, 2016, 5:54 AM by Maciek J Swat
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